The Genomics CoLab offers multiple genomic technologies to aid investigators in utilizing the power bulk, single cell and spatial transcriptomics in their research programs. We also support whole genome/exome DNA-sequencing and multiple types of epigenenomic assays from bulk ATAC-seq, CUT&Run, CUT&TAG and single cell ATAC-seq.
We work with investigators from experimental design and assay selection through sample processing, library preparation, sequencing coordination, data analysis, and interpretation. Choosing the right method begins with the biological question. The summaries below provide a starting point; each service page includes additional information about assay options, accepted samples, experimental design, data deliverables, and pricing considerations.
Bulk RNA sequencing
Measure average gene expression across tissues, cultured cells, sorted populations, or other biological samples. We offer standard mRNA-seq and low-input workflows for projects ranging from conventional differential-expression studies to very small cell populations.
Learn more about bulk RNA sequencing.
Small RNA sequencing
Profile microRNAs and other compatible small-RNA species that are not captured well by standard poly(A)-selected mRNA sequencing. Small RNA-seq can support studies of post-transcriptional regulation, extracellular RNAs, and condition-dependent changes in small-RNA abundance.
Learn more about small RNA sequencing.
DNA sequencing
Investigate genomic variation using whole-genome sequencing, whole-exome sequencing, or other compatible DNA library-preparation workflows. We help define the appropriate coverage, sequencing design, and analysis approach based on the organism and the types of variants the project must detect.
Learn more about DNA sequencing.
### Bulk epigenomic assays
Study the gene regulatory environment through chromatin accessibility, histone modifications, and chromatin-associated proteins using ATAC-seq, CUT&RUN, and CUT&Tag. Assay selection depends on whether the project requires a broad measurement of accessible chromatin or mapping of a specific protein or histone mark.
Learn more about bulk epigenomic assays.
Single-cell and single-nucleus omics
Resolve gene expression and chromatin measurements at the level of individual cells or nuclei. Our offerings include 10x Genomics 3' and 5' Gene Expression, On-Chip Multiplexing, Flex fixed-sample Gene Expression, immune-receptor and Feature Barcode additions, single-nucleus ATAC, and RNA-plus-ATAC Multiome workflows.
Learn more about single-cell and single-nucleus omics.
Spatial transcriptomics
Measure gene expression while preserving its location within a tissue section. We support Visium HD for broad spatial transcriptome discovery and Xenium for targeted single-cell and subcellular RNA localization, along with project-specific support for tissue preparation, imaging, segmentation, and analysis.
Learn more about spatial transcriptomics.
Not sure which assay to choose?
The best assay depends on the biological question, sample type and preservation, number of samples, required resolution, sequencing needs, budget, and analysis plan. The Genomics CoLab can help compare suitable methods, identify sample-preparation requirements, plan biological replicates and controls, and prepare a project-specific estimate.
Learn how to start a project.
Need help with bioinformatic analysis?
We also offer various levels of analytical support for all the assays we preform. Depending on assay type or investigator needs, we can process raw data files to counts matrices and provide quality control metrics, carry out unsupervised analysis such as principal component analysis, dimensionality reduction, clustering, spatial niche analysis, or supervised analysis such as SNP calling, peaking calling, cell type annotations, differential gene analysis and pathway analysis.
Learn more about our bioinformatics analysis capabilities.